Izzie Stevens had cancer. Alex married her and she survived. Then, it was kind of like the sixth season. In the end, she returned to Seattle for another season and said that Seattle no longer felt like her home. Later, Alex got sent divorce papers, and now we know Izzie secretly had Alex’s twins, lives on a ranch in Kansas, and became a surgical oncologist.
Katherine HeiglThe reason for her departure was that she pulled out of Emmy consideration in 2008 because she felt the material didn’t deserve it. The character vanished completely in 2010 Shonda Rhimes denied that she had ever wished to go back to the character in all the years. She told TVLine that she was done with the story in 2015.
Heigl became a star in many romcoms, before returning to TV. The State of the AffairsIf so, DoubtRecently, she was also a member SuitsThe 2020 Series Firefly Lane.