Izzie Stevens had cancer. Alex married her and she survived. Then, it was kinda like everything just vanished in season six. In the end, she returned to Seattle for another season and said that Seattle no longer felt like her home. Later, Alex got sent divorce papers, and now we know Izzie secretly had Alex’s twins, lives on a ranch in Kansas, and became a surgical oncologist. 

Katherine HeiglHer exit began in 2008, when she decided she did not feel the material was worthy of her name being included on Emmy ballots. In 2010, her character vanished completely. Shonda Rhimes denied that she had ever wished to return to the character in all the years. TVLine reported that she said, “I’m done” with this story in 2015. 

Heigl was a rising star of romcoms and went on to appear in several more before returning to television. The State of the AffairsIf so, DoubtShe was a member of the Advisory Board, which she also joined recently SuitsAnd the 2020 series Firefly Lane.